Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-06T12:46:50 RDF description of Metabolic disorders with clinical and radiologic features of sporadic Creutzfeldt-Jakob disease - http://repository.healthpartners.com/individual/document-rn796 Brain 5 Dementia public Mental Disorders document-rn796 2022-02-21T22:48:57.408-06:00 Metabolic disorders with clinical and radiologic features of sporadic Creutzfeldt-Jakob disease 12716 Neurology. Clinical practice 20012 2 <p>Two patients with metabolic disorders presented with clinical and radiologic features suggestive of sporadic Creutzfeldt-Jakob disease (sCJD). Case 1 was a 50-year-old man with rapid decline in cognitive, behavioral, and motor function following new-onset seizures. MRI was read as consistent with CJD, and he was referred for a treatment trial, but it was determined that he recently experienced rapid correction of hyponatremia resulting in extrapontine myelinolysis. Case 2 was a 66-year-old woman with poorly controlled diabetes mellitus who was found unconscious after a suspected insulin overdose. Examination showed altered mental status and neuroimaging was remarkable for cortical/striatal hyperintensities suggestive of sCJD. On autopsy, she had hypoglycemic/hypoxic nerve cell loss. Although characteristic MRI findings have high sensitivity and specificity for sCJD, potentially reversible metabolic disorders sometimes present rapidly and can resemble sCJD both clinically and radiologically. These cases highlight the importance of establishing a broad differential diagnosis when evaluating a patient with suspected sCJD.<p> 10.1212/CPJ.0000000000000114 Nervous System Diseases