Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-07T15:04:12 RDF description of Existing and novel biological therapeutics in suicide prevention - http://repository.healthpartners.com/individual/document-rn7269 Biomarkers Existing and novel biological therapeutics in suicide prevention <p>We summarize outcomes for several pharmacologic and neurostimulatory approaches that have been considered potential treatments to reduce suicide risk, namely, by reducing suicide deaths, attempts, and ideation in various clinical populations. Available treatments include clozapine, lithium, antidepressants, antipsychotics, electroconvulsive therapy, and transcranial magnetic stimulation. The novel repurposing of ketamine as a potential suicide risk-mitigating agent in the acute setting is also discussed. Research pathways to better understand and treat suicidal ideation and behavior from a neurobiological perspective are proposed in light of this foundation of information and the limitations and challenges inherent in suicide research. Such pathways include trials of fast-acting medications, registry approaches to identify appropriate patients for trials, identification of biomarkers, neuropsychological vulnerabilities, and endophenotypes through the study of known suicide risk-mitigating agents in hope of determining mechanisms of pathophysiology and the action of protective biological interventions.<p> 3 Suppl 2 American Journal of Preventive Medicine Antidepressive Agents 20810 Suicide document-rn7269 public 10.1016/j.amepre.2014.06.012 13115 2022-02-21T22:48:57.408-06:00 Drugs and Drug Therapy 47 Prevention Mental Disorders