Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-06-24T01:53:31 RDF description of Comparison of single- versus two-stage revision knee arthroplasty for the treatment of periprosthetic knee joint infections - http://repository.healthpartners.com/individual/document-rn47367 two-stage revision 24153 2025-05-30T21:37:53.551-05:00 Periprosthetic joint infection public Journal of Arthroplasty 41846 Surgery Comparison of single- versus two-stage revision knee arthroplasty for the treatment of periprosthetic knee joint infections TKA revision total knee arthroplasty revision document-rn47367 Knee <p>BACKGROUND: Periprosthetic joint infection (PJI) can be a complex and distressing complication following total knee arthroplasty (TKA). Both one-stage and two-stage revisions are the main options for treating chronic PJI of the knee; however, the best treatment option continues to be debated. We aimed to compare the rate of success by comparing the risk of re-infection between the two treatment options. <br>METHODS: Patients who underwent one-stage from 2009 to 2014 or two-stage revision from 2015 to 2020 for treatment of PJI of the knee were included. The Delphi-based consensus criteria were used to classify infections. The primary outcome was recurrent infection. Time from the index revision surgery to the return to the operating room for infectious reasons and non-infectious reasons was compared between the two groups. <br>RESULTS: A total of 66 patients underwent knee revision for PJI, in which 46 (69.7%) underwent one-stage and 20 (30.3%) underwent two-stage revision. Mean age (P = 0.57) and body mass index (BMI) (P = 0.33) were similar between the groups. The rate of no recurrence of infection was 89.1% in the one-stage group and 65.0% in the two-stage group (P = 0.034) at the mean follow-up time of 5.4 years (range, 2.2 to 10.3). The one-stage group was significantly more likely to have decreased time between the revision for re-infection (P = 0.012). There were no significant differences in rates of postoperative deep vein thrombosis, acute renal failure, long-term antibiotic use, or length of stay. <br>CONCLUSIONS: These results indicate that one-stage revision for treatment of PJI of the knee is at least as effective as two-stage revision. To our knowledge, this is the largest single-surgeon, single-protocol series of consecutive cases reported to date, with limited exclusion criteria.<p> one-stage revision PJI 10.1016/j.arth.2025.05.041 Orthopedics