Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-06-25T02:50:43 RDF description of Cross-reactivity of urine opiates screening assays with dextromethorphan - http://repository.healthpartners.com/individual/document-rn47366 document-rn47366 24171 Drugs and Drug Therapy 2025-05-30T21:37:53.551-05:00 41882 Screening public 575 Clinica Chimica Acta Cross-reactivity of urine opiates screening assays with dextromethorphan 10.1016/j.cca.2025.120378 <p>We present a case of high-dose dextromethorphan ingestion with associated rapid urine drug screening and confirmatory testing demonstrating an apparent false-positive opiates screen. Further testing was performed using alternative screening assays and analysis of drug-free matrices spiked with various concentrations of dextromethorphan and its metabolite, dextrorphan. Results demonstrate a subset of urine opiates screening assays may be susceptible to dextromethorphan cross-reactivity at high concentrations.<p> Substance Abuse