Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-06-25T11:06:20 RDF description of Low magnesium levels and prognosis in newly diagnosed diffuse large B-cell lymphoma - http://repository.healthpartners.com/individual/document-rn47358 Cancer 12 Blood Low magnesium levels and prognosis in newly diagnosed diffuse large B-cell lymphoma 10.1093/oncolo/oyae255 24142 public document-rn47358 2025-05-30T21:37:53.551-05:00 <p>Magnesium (Mg) is an essential element involved in cellular metabolism. We demonstrated that in patients with diffuse large B-cell lymphoma (DLBCL) undergoing autologous stem cell transplant (SCT), those with a serum Mg�<�2.0 mg/dL at the time of transplant had worse outcomes. In this study, we aimed to learn the prognostic value of low serum Mg in patients with untreated DLBCL. We analyzed serum from 408 patients and tested 2 Mg cutpoints-low (<1.7 mg/dL) and low normal (<2.0 mg/dL), a range we found associated with lower survival in the SCT group. We found 3% of patients with low levels and 23% with low normal levels. Low normal serum Mg levels were associated with a higher stage at diagnosis, more extranodal involvement, higher international prognostic index score, lower overall survival (OS), and event-free survival. These data warrant testing Mg replacement to a target of >2.0 mg/dL to learn if survival can be improved.<p> 29 The oncologist 41824