Article Document Information Content Entity Continuant Continuant Entity Entity Review Generically Dependent Continuant 2025-05-06T12:51:29 RDF description of Brain glucose hypometabolism and brain iron accumulation as therapeutic targets for Alzheimer's disease and other CNS disorders [review] - http://repository.healthpartners.com/individual/document-rn45971 Drugs and Drug Therapy 18 review public 10.3390/ph18020271 Intranasal Administration 41380 Brain glucose hypometabolism and brain iron accumulation as therapeutic targets for Alzheimer's disease and other CNS disorders [review] <p>Two common mechanisms contributing to multiple neurological disorders, including Alzheimer's disease, are brain glucose hypometabolism (BGHM) and brain iron accumulation (BIA). Currently, BGHM and BIA are both widely acknowledged as biomarkers that aid in diagnosing CNS disorders, distinguishing between disorders with similar symptoms, and tracking disease progression. Therapeutics targeting BGHM and BIA in Alzheimer's disease can be beneficial in treating neurocognitive symptoms. This review addresses the evidence for the therapeutic potential of targeting BGHM and BIA in multiple CNS disorders. Intranasal insulin, which is anti-inflammatory and increases brain cell energy, and intranasal deferoxamine, which reduces oxidative damage and inflammation, represent promising treatments targeting these mechanisms. Both BGHM and BIA are promising therapeutic targets for AD and other CNS disorders.<p> 2025-02-28T22:09:50.325-06:00 2 document-rn45971 Brain Alzheimer’s Disease 23880 Pharmaceuticals (Basel, Switzerland)