Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-07T17:35:03 RDF description of Reduction of immune activation with chloroquine therapy during chronic HIV infection - http://repository.healthpartners.com/individual/document-rn38522 41206 22 CD4-Positive T-Lymphocytes/drug effects/immunology Ki-67 Antigen/immunology document-rn38522 23793 84 Chloroquine/*administration & dosage Cells, Cultured <p>Increased levels of activated T cells are a hallmark of the chronic stage of human immunodeficiency virus (HIV) infection and are highly correlated with HIV disease progression. We evaluated chloroquine (CQ) as a potential therapy to reduce immune activation during HIV infection. We found that the frequency of CD38(+) HLA-DR(+) CD8 T cells, as well as Ki-67 expression in CD8 and CD4 T cells, was significantly reduced during CQ treatment. Our data indicate that treatment with CQ reduces systemic T-cell immune activation and, thus, that its use may be beneficial for certain groups of HIV-infected individuals.<p> Journal of Virology Leukocytes, Mononuclear/drug effects/immunology Down-Regulation/*drug effects Lymphocyte Activation/drug effects public 2025-02-14T21:34:35.132-06:00 Humans Reduction of immune activation with chloroquine therapy during chronic HIV infection CD8-Positive T-Lymphocytes/drug effects/immunology 10.1128/jvi.01466-10 Chronic Disease/therapy HIV Infections/*drug therapy/*immunology