Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-08T04:49:26 RDF description of Diagnosis and treatment of malaria in children - http://repository.healthpartners.com/individual/document-rn38494 2025-02-14T21:34:35.132-06:00 Drug Combinations 41182 document-rn38494 Sulfadoxine/therapeutic use Antimalarials/*therapeutic use <p>Malaria continues to be a problem for children returning or immigrating to industrialized countries from tropical regions. Proper diagnosis begins with clinical suspicion. In nonimmune children, malaria typically presents with high fever that might be accompanied by chills and headache. Symptoms and signs may be more subtle in partially immune children, and anemia and hepatosplenomegaly may also be present. Children may present with respiratory distress and/or rapidly progressing cerebral malaria that manifests as altered sensorium and, sometimes, seizures. Thick blood smears help to determine when infection is present, but a single smear without parasites is not sufficient to rule out malaria. Thin blood smears aid in identifying the species of parasite. Treatment must include careful supportive care, and intensive care measures should be available for treating children with complicated Plasmodium falciparum malaria. Medical regimens can include mefloquine, atovaquone-proguanil, sulfadoxine-pyrimethamine, quinine or quinidine, clindamycin, doxycycline, chloroquine, and primaquine.<p> public 23781 Malaria/diagnosis/drug therapy 10.1086/379074 10 Clinical Infectious Diseases Naphthoquinones/therapeutic use Animals Mefloquine/therapeutic use *Plasmodium falciparum Diagnosis and treatment of malaria in children Pyrimethamine/therapeutic use Child 37 Malaria, Falciparum/diagnosis/*drug therapy Atovaquone Chloroquine/therapeutic use Humans Proguanil/therapeutic use