Article Document Information Content Entity Continuant Continuant Entity Entity Review Generically Dependent Continuant 2025-06-25T06:16:10 RDF description of Epidemiology and genetics of early onset colorectal cancer-African overview with a focus on Ethiopia [review] - http://repository.healthpartners.com/individual/document-rn32702 1-2 10.1053/j.seminoncol.2023.03.007 Global Health <p>Colorectal cancer (CRC) is a common cause of cancer-related death worldwide, with high rates of late diagnosis and increased mortality in sub-Saharan Africa. Furthermore, there is an alarming uptrend in the incidence of early onset colorectal cancer (EOCRC) across the globe, thus necessitating the need for early screening in general and special populations. There is, however, limited data available on the incidence and genetic characteristics of EOCRC from resource-poor countries, particularly Africa. Moreover, there is lack of clarity if recommendations and mechanisms proposed based on data from resource-rich countries applies to other regions of the world. In this review, we appraise the literature on EOCRC, its overall incidence, and genetic components as it pertains to sub-Saharan Africa. In addition, we highlight epidemiologic and epigenetic findings of our EOCRC cohort in Ethiopia.<p> Colorectal Cancer 21273 Seminars in Oncology 36486 2023-06-30T21:52:02.627-05:00 document-rn32702 review public Epidemiology and genetics of early onset colorectal cancer-African overview with a focus on Ethiopia [review] Mortality 50