Document Information Content Entity Continuant Continuant Abstract Entity Entity Generically Dependent Continuant 2025-05-06T10:56:27 RDF description of Chronic kidney disease is a significant risk factor of pocket hematoma formation after pacemaker and implantable cardioverter-defibrillator placement independent of anticoagulation and antiplatelet agents [abstract] - http://repository.healthpartners.com/individual/document-rn30636 Surgery 55 Journal of the American College of Cardiology Retrospective Studies public 10 Suppl 1 Heart Diseases document-rn30636 2022-02-21T22:48:57.408-06:00 Kidney Diseases 35198 Risk Factors abstract Chronic kidney disease is a significant risk factor of pocket hematoma formation after pacemaker and implantable cardioverter-defibrillator placement independent of anticoagulation and antiplatelet agents [abstract] <p>Background: Pocket hematoma formation is a common complication after pacemaker and implantable cardioverter-defibrillator (ICD) placement. In this study, we investigated the influence of patients' comorbidities on the rate of pocket hematoma formation after pacemaker and ICD placement.<br>Methods: This study retrospectively evaluated a cohort of 458 patients(male 65%, mean age 71) who underwent pacemaker and ICD placement at Regions Hospital in St. Paul, MN from 01/2004 to 08/2008. Fifty seven percent patients were on warfarin, 27% on intravenous heparin or subcutaneous enoxaparin and 66% were on antiplatelet therapy at the time of device implantation. Predictors of pocket hematoma formation were analyzed by multivariate regression analysis. A P value of .0.05 was considered significant.<br>Results: The incidence of pocket hematoma was 2.2%. After adjusting for anticoagulation and antiplatelet agents, chronic kidney disease was found to be a significant risk factor of pocket hematoma formation after device implantation by multivariate regression analysis (Table). An increase of 1.0 mg/dl in creatinine levels was associated with two times higher rate of hematoma formation (OR 1.99, 95% CI 1.22-3.21, P=0.03).<br>Conclusions: Chronic kidney disease was found to be a significant risk factor of pocket hematoma formation after pacemaker and ICD placement<br>independent of anticoagulation and antiplatelet agents.<br><br>Predictors of pocket hematoma (multivariate regression analysis)<br>Predictor OR estimate, 95% CI P Value<br>Age 1.015 (0.96, 1.07) 0.61<br>Female Vs Male 2.20 (0.46, 10.5) 0.50<br>Obesity(BMI.30 kg/m2 ) 1.10 (0.98, 1.24) 0.09<br>Chronic Kidney Disease 4.37 (1.06, 18.1) 0.04<br>Diabetes Mellitus 0.57 (0.07, 4.98) 1.00<br>Hypertension 1.35 (0.17, 11.0) 1.00<br>Anemia(Hg<12 g/dl) 1.07(0.73, 1.57) 0.74<br>Smoking 1.15(0.30,4.37) 0.73<p> 20549