Article Document Academic Article Information Content Entity Journal Article Continuant Continuant Entity Entity Generically Dependent Continuant 2025-05-09T01:45:08 RDF description of Inflammation, attention, and processing speed in patients with breast cancer before and after chemotherapy - http://repository.healthpartners.com/individual/document-rn28031 114 document-rn28031 10.1093/jnci/djac022 5 Journal of the National Cancer Institute Drugs and Drug Therapy Chemotherapy Brain 2022-02-21T22:48:57.408-06:00 Breast Cancer <p>BACKGROUND: Inflammation may contribute to cognitive difficulties in patients with breast cancer. We tested 2 hypotheses: inflammation is elevated in patients with breast cancer vs noncancer control participants and inflammation in patients is associated with worse attention and processing speed over the course of chemotherapy. METHODS: Serum cytokines (interleukin [IL]-4, 6, 8, 10; tumor necrosis factor [TNF]-α) and soluble receptors [sTNFRI, II]) were measured in 519 females with breast cancer before and after chemotherapy and 338 females without cancer serving as control participants. Attention and processing speed were measured by Rapid Visual Processing (RVP), Backward Counting (BCT), and Trail Making-A (TMT-A) tests. Linear regression models examined patient vs control cytokines and receptor levels, adjusting for covariates. Linear regression models also examined relationships between patient cytokines and receptor levels and test performance, adjusting for age, body mass index, anxiety, depression, cognitive reserve, and chemotherapy duration. Statistical tests were 2-sided (α�=�.05). RESULTS: sTNFRI and sTNFRII increased over time in patients relative to controls, whereas IL-4, IL-6, and IL-10 decreased. Prechemotherapy, higher IL-8 associated with worse BCT (β�=�0.610, SE�=�0.241, P�=�.01); higher IL-4 (β = -1.098, SE�=�0.516, P�=�.03) and IL-10 (β = -0.835, SE�=�0.414, P�=�.04) associated with better TMT-A. Postchemotherapy, higher IL-8 (β�=�0.841, SE�=�0.260, P = .001), sTNFRI (β�=�6.638, SE�=�2.208, P�=�.003), and sTNFRII (β�=�0.913, SE�=�0.455, P�=�.045) associated with worse BCT; higher sTNFRII also associated with worse RVP (β = -1.316, SE�=�0.587, P�=�.03). At prechemotherapy, higher IL-4 predicted RVP improvement over time (β�=�0.820, SE�=�0.336, P�=�.02); higher sTNFRI predicted worse BCT over time (β�=�5.566, SE�=�2.367, P�=�.02). Longitudinally, increases in IL-4 associated with BCT improvement (β = -0.564, SE�=�0.253, P�=�.03). CONCLUSIONS: Generally, worse attention and processing speed were associated with higher inflammatory cytokines and receptors and lower anti-inflammatory cytokines in patients; future confirmatory studies are needed.<p> 33874 19827 Inflammation, attention, and processing speed in patients with breast cancer before and after chemotherapy public