Article Document Academic Article Information Content Entity Journal Article Continuant Continuant Entity Entity Generically Dependent Continuant 2025-05-06T18:01:15 RDF description of Compositional evaluation of lesion and parent bone in patients with juvenile osteochondritis dissecans of the knee using T(2) * mapping - http://repository.healthpartners.com/individual/document-rn28000 19832 Radiography 2022-02-21T22:48:57.408-06:00 document-rn28000 33884 40 10.1002/jor.25187 <p>Juvenile osteochondritis dissecans (JOCD) lesions contain cartilaginous, fibrous and osseous tissues which are difficult to distinguish with clinical, morphological magnetic resonance imaging (MRI). Quantitative T(2) * mapping has earlier been used to evaluate microstructure and composition of all aforementioned tissues as well as bone mineral density. However, the ability of T(2) * mapping to detect changes in tissue composition between different JOCD lesion regions, different disease stages, and between stable and unstable lesions has not been demonstrated. This study analyzed morphological and T(2) * MRI data from 25 patients (median age, 12.1 years) with 34 JOCD-affected and 13 healthy knees. Each lesion was assigned a stage reflecting the natural history of JOCD, with stages I and IV representing early and healed lesion, respectively. T(2) * values were evaluated within the progeny lesion, interface and parent bone of each lesion and in the control bone region. T(2) * was negatively correlated with JOCD stage in progeny lesion (ρ��=��-0.871; p��<��0.001) and interface regions (ρ��=��-0.649; p��<��0.001). Stage IV progeny showed significantly lower T(2) * than control bone (p��=��0.028). T(2) * was significantly lower in parent bone than in control bone of patients with stable lesions (p��=��0.009), but not in patients with unstable lesions (p��=��0.14). Clinical significance: T(2) * mapping enables differentiation between different stages of JOCD and quantitative measurement of the ossification degree in progeny lesion and interface. The observed T(2) * decrease in healed and stable lesions may indicate increased bone density as a result of the active repair process. T(2) * mapping provides quantitative information about JOCD lesion composition.<p> Orthopedics 7 Retrospective Studies Compositional evaluation of lesion and parent bone in patients with juvenile osteochondritis dissecans of the knee using T(2) * mapping Journal of Orthopaedic Research Pediatrics Bone Density public Knee