Document Information Content Entity Continuant Continuant Conference Poster Entity Entity Generically Dependent Continuant 2025-05-06T12:50:05 RDF description of Nasal delivery of lidocaine decreases carrageenan-induced orofacial pain [poster] - http://repository.healthpartners.com/individual/document-rn27147 32754 poster Pain Nasal delivery of lidocaine decreases carrageenan-induced orofacial pain [poster] document-rn27147 public Drugs and Drug Therapy Animal Studies 19247 Intranasal Administration 2022-02-21T22:48:57.408-06:00 <p>Objectives: Intranasal lidocaine has been demonstrated to target the trigeminal nerve and decrease trigeminal neuralgia pain in humans. This study used a novel behavior apparatus to assess the effect of intranasal lidocaine in a rat model of carrageenan-induced orofacial pain.<br>Methods: The TrigeminAir behavior apparatus was used, which is designed to present air pressure on the sensitized, carrageenan-inflamed whisker pad and electronically measure sip rate of a sweetened condensed milk reward. A computer continuously recorded sip rate for six rats simultaneously.<br>Results: Increased doses of carrageenan (0%, 2%, and 4%) resulted in decreased sip rate (p<0.01) in the TrigeminAir from 5 to 12 hours post-carrageenan injection. Intranasal 10% lidocaine reversed (p<0.05) the effects of carrageenan on sip rate compared to intranasal 0% lidocaine.<br>Conclusions: These results along with previously published evidence indicate that intranasal lidocaine is an effective trigeminal nerve block to orofacial structures. TrigeminAir is a novel method of screening for orofacial pain models and treatments in rats, particularly trigeminal neuralgia.<p> Dental Care