Presentation Event Entity Entity Process Occurrent Occurrent 2025-05-06T10:48:12 RDF description of Use of an impedance threshold device with active compression decompression cardiopulmonary resuscitation improves survival with good neurologic function following cardiac arrest from non-traumatic etiologies [presentation] - http://repository.healthpartners.com/individual/document-rn26877 public 19503 33266 European Resuscitation Council (ERC) Congress Use of an impedance threshold device with active compression decompression cardiopulmonary resuscitation improves survival with good neurologic function following cardiac arrest from non-traumatic etiologies [presentation] Resuscitation 2022-02-21T22:48:57.408-06:00 document-rn26877 presentation Emergency Medicine <p>Background: Adding an impedance threshold device (ITD) to active compression decompression CPR (ACD-CPR) has been shown to significantly improve long-term survival with favorable neurologic outcome following out-of-hospital cardiac arrest (OOHCA) of cardiac etiology. We hypothesized that ITD+ACDCPR would also increase survival with good neurologic function from all non-traumatic etiologies compared to standard CPR (SCPR). Methods: This prospective, randomized trial evaluated adults with OOHCA in seven US study sites. Patients were randomized to ITD+ACD-CPR or S-CPR on a 1:1 proportional basis. CPR was initiated by the first arriving EMS provider. A run-in phase preceded the pivotal phase to assure study logistics were well-coordinated. A pre-planned analysis was conducted on data from all non-traumatic arrest patients with known outcomes, prospectively randomized into the run-in and pivotal phases (combined), on an intention-to-treat basis. The primary endpoint was survival to hospital discharge (HD) with good neurologic function, defined as a modified Rankin Score (MRS) .3; and at one year, a Cerebral Performance Category (CPC) score .2. Statistical analysis was performed using a 2-sided Fischer's Exact Test. Results: Both groups had similar clinical profiles, baseline demographics and resuscitative efforts. Survival to HD with MRS .3 was achieved in 5.69% (75/1318) in the S-CPR group, and 7.88% (110/1396) in the ITD+ACD-CPR group, p= 0.027 [Odds ratio=1.42 (95% confidence interval= 1.04,1.95)]. Survival to one year with CPC .2 was achieved in 4.71% (61/1296) in the S-CPR group, and 6.38% (86/1349) in the ITD+ACDCPR group, p= 0.062 [Odds ratio=1.38 (95% confidence interval= 0.97,1.96)]. Conclusion: Compared to S-CPR, ITD+ACD-CPR resulted in a 38.5% increase in survival to hospital discharge with favorable neurologic function (p=0.027), and a 35.4% increase in survival at one year with favorable neurologic function (not significant). These findings support the use of ITD+ACD-CPR for treatment of adults with OOHCA from a variety of non-traumatic etiologies.<p> Cardiovascular Diseases