Article Document Academic Article Information Content Entity Journal Article Continuant Continuant Entity Entity Generically Dependent Continuant 2025-05-07T17:32:51 RDF description of Association of adiponectin and vitamin D with tumor infiltrating lymphocytes and survival in stage III colon cancer - http://repository.healthpartners.com/individual/document-rn26811 2022-02-21T22:48:57.408-06:00 <p>BACKGROUND: Adipocyte-derived adiponectin may play a role in the host inflammatory response to cancer. We examined the association of plasma adiponectin with the density of tumor-infiltrating lymphocytes (TILs) in colon cancers and with vitamin D, clinicopathological features, and patient survival. METHODS: Plasma adiponectin and 25-hydroxyvitamin D [25(OH)D] were analyzed by radioimmunoassay in 600 patients with stage III colon cancer who received FOLFOX-based adjuvant chemotherapy (NCCTG N0147 [Alliance]). TIL densities were determined in histopathological sections. Associations with disease-free survival (DFS), time to recurrence, and overall survival were evaluated by multivariable Cox regression adjusting for potential confounders (ie, body mass index, race, TILs, and N stage). All statistical tests were 2-sided. RESULTS: We found a statistically significant reduction in adiponectin, but not 25(OH)D, levels in tumors with high vs low TIL densities (median�=�6845 vs 8984 ng/mL; P = .04). A statistically significant reduction in adiponectin was also observed in obese (body mass index >30 kg/m(2)) vs nonobese patients (median�=�6608 vs 12 351 ng/mL; P�<�.001), in men vs women (median�=�8185 vs 11 567 ng/mL; P�<�.001), in Blacks vs Whites or Asians (median�=�6412 vs 8847 vs 7858 ng/mL; P�<�.03), and in those with fewer lymph node metastases (N1 vs N2: median�=�7768 vs 9253 ng/mL; P�=�.01). Insufficiency of 25(OH)D (<30 ng/mL) was detected in 291 (48.5%) patients. In multivariable analyses, neither adiponectin nor 25(OH)D were associated with a statistically significant difference in DFS, overall survival , or time to recurrence in models adjusted for potential confounders. We found a statistically significant association of TILs with prognosis, yet no such interaction was observed for the association of adiponectin with TILs for DFS. CONCLUSIONS: Lower circulating adiponectin levels were associated with a statistically significant increase in TIL densities in colon cancers, indicating an enhanced antitumor immune response. In contrast to TILs, neither adiponectin nor 25(OH)D was independently prognostic.<p> document-rn26811 Association of adiponectin and vitamin D with tumor infiltrating lymphocytes and survival in stage III colon cancer 32082 18901 Mortality Racial Groups Blood Randomized Controlled Trials 10.1093/jncics/pkab070 5 JNCI cancer spectrum Dietary Supplements Colorectal Cancer public Drugs and Drug Therapy 5