Article Document Academic Article Information Content Entity Journal Article Continuant Continuant Entity Entity Generically Dependent Continuant 2025-05-07T21:00:29 RDF description of Longitudinal change in quality of life in neurological disorders measures over 3 years in patients with early Parkinson's disease - http://repository.healthpartners.com/individual/document-rn26229 Parkinson Disease 36 Quality of Life Measurement 31144 18412 Movement Disorders document-rn26229 public 8 <p>BACKGROUND: The Quality of Life in Neurological Disorders (Neuro-QoL) is a publicly available health-related quality-of-life measurement system. OBJECTIVE: The aim of this study was to evaluate the utility of Neuro-QoL item banks as outcome measures for clinical trials in Parkinson's disease. METHODS: An analysis of Neuro-QoL responsiveness to change and construct validity was performed in a multicenter clinical trial cohort. RESULTS: Among 310 participants over 3 years, changes in five of eight Neuro-QoL domains were significant (P <�0.05) but very modest. The largest effect sizes were seen in the cognition and mobility domains (0.35-0.39). The largest effect size for change over the year in which levodopa was initiated was -0.19 for lower extremity function-mobility. For a similarly designed clinical trial, estimated sample size required to demonstrate a 50% reduction in worsening ranged from 420 to more than 1000 participants per group. CONCLUSIONS: More sensitive tools will be required to serve as an outcome measure in early Parkinson's disease.<p> 2022-02-21T22:48:57.408-06:00 Drugs and Drug Therapy Longitudinal change in quality of life in neurological disorders measures over 3 years in patients with early Parkinson's disease 10.1002/mds.28641