Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-10T17:16:48 RDF description of Bilateral vestibular schwannomas in a patient with ring chromosome 22: case report and review of the literature - http://repository.healthpartners.com/individual/document-rn25475 30686 1 public 18173 56 Nervous System Diseases Bilateral vestibular schwannomas in a patient with ring chromosome 22: case report and review of the literature Surgery document-rn25475 10.1159/000513112 Ear Pediatric Neurosurgery <p>INTRODUCTION: Ring chromosome 22 (r[22]) can lead to the development of intracranial tumors such as meningiomas, neurofibromas, and schwannomas similar to neurofibromatosis 2 (NF2). CASE PRESENTATION: An 18-year-old female with r(22) and a history of global development delay and cognitive impairment presented with sudden hearing loss. MRI revealed bilateral vestibular schwannomas. Given documented audiologic decline in the patient's hearing, the larger tumor was treated with CyberKnife fractionated stereotactic radiosurgery, and the smaller tumor is being monitored. CONCLUSION: This case provides further evidence that patients with r(22) can develop clinical features of NF2, including the development of bilateral vestibular schwannomas, and should be monitored for hearing disturbances starting in puberty as a warning sign for these tumors.<p> Pediatrics 2022-02-21T22:48:57.408-06:00 Brain Cancer