Article Document Information Content Entity Continuant Continuant Entity Entity Review Generically Dependent Continuant 2025-05-10T00:54:01 RDF description of Comparison of second-generation basal insulin analogs: a review of the evidence from continuous glucose monitoring [review] - http://repository.healthpartners.com/individual/document-rn23836 Diabetes review Comparative Studies 18044 public 1 23 2022-02-21T22:48:57.408-06:00 Comparison of second-generation basal insulin analogs: a review of the evidence from continuous glucose monitoring [review] Blood Diabetes Technology & Therapeutics 30428 <p>Many people with insulin-treated diabetes continue to experience inadequate glycemic control and a high incidence of hypoglycemic events, despite improvements in therapeutic strategies. While glycated hemoglobin (HbA(1c)) is currently recognized as the gold-standard for assessing glycemic control, the measure reflects mean blood glucose levels over a period of time, does not inform on acute glycemic deviations, and can be unreliable in certain populations. Continuous glucose monitoring (CGM) facilitates the acquisition of blood glucose data around the clock and, importantly, predicts and/or captures acute hyper- and hypoglycemic episodes. In light of the recent publication of the Time in Range (TIR) International Consensus Group report on key CGM metrics, we performed a review of current CGM evidence for second-generation basal insulins in both people with type 1 and type 2 diabetes. The identified studies highlight the varied CGM-related metrics used to assess basal insulins, which complicate comparisons. Furthermore, all studies had small sample sizes and typically were of short duration, which may account for the lack of statistically significant between-treatment differences observed. Differences were seen in the titration approaches used and the settings in which participants were observed. These results highlight the need for further studies of second-generation basal insulin analogs that are designed to capture the standard metrics proposed by the TIR consensus group, with additional consideration given to sample size and study duration.<p> document-rn23836 Monitoring, Physiologic Drugs and Drug Therapy 10.1089/dia.2020.0180