Article Document Information Content Entity Continuant Continuant Entity Entity Review Generically Dependent Continuant 2025-05-07T15:15:43 RDF description of Intratumoral generation of 2-fluoroadenine to treat solid malignancies of the head and neck [review] - http://repository.healthpartners.com/individual/document-rn22255 Head Clinical Trials 2022-02-21T22:48:57.408-06:00 <p>This report describes treatment of locoregional head and neck squamous cell carcinoma (HNSCC) by an innovative, experimental strategy involving generation of a robust anti-cancer agent (2-fluoroadenine [F-Ade]) following transduction by Escherichia coli purine nucleoside phosphorylase (PNP) in a small number of tumor cells. F-Ade works by a unique mechanism of action (ablation of RNA and protein synthesis) and confers tumor regressions of otherwise refractory HNSCC in human subjects. Clinical studies have now advanced to a pivotal (registration-directed) trial involving locoregional HNSCC, with plans to begin subject enrollment late in 2018. The present review is the first to summarize use of PNP in the context of HNSCC, and provides background regarding this emerging anti-cancer approach.<p> Cancer 17053 41 review 6 Head and Neck document-rn22255 28586 10.1002/hed.25627 Chemotherapy Intratumoral generation of 2-fluoroadenine to treat solid malignancies of the head and neck [review] public Drugs and Drug Therapy