Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-09T01:35:19 RDF description of Phase 1b study of IGF-methotrexate conjugate in the treatment of high-grade myelodysplastic syndromes - http://repository.healthpartners.com/individual/document-rn21836 Drugs and Drug Therapy Anticancer Research 40 7 16952 10.21873/anticanres.14378 Blood Chemotherapy document-rn21836 Phase 1b study of IGF-methotrexate conjugate in the treatment of high-grade myelodysplastic syndromes Cancer <p>BACKGROUND/AIM: The insulin-like growth factor type 1 receptor (IGF-1R) is overexpressed in myelodysplastic syndrome (MDS) cells, and 765IGF-Methotrexate (IGF-MTX) is a conjugate of methotrexate and a variant of insulin-like growth factor-1 (IGF-1) designed to selectively target cancer cells through binding to IGF-1R. The aim of this study was to determine whether IGF-MTX would be effective to treat MDS. PATIENTS AND METHODS: In this phase I clinical trial, two patients with high grade MDS or oligoblastic acute myeloid leukemia (O-AML) that had failed standard therapy were treated with IGF-MTX. RESULTS: No dose-limiting toxicity was observed. Both patients had stable or improved cell counts and CD34+ myelodysplastic cell counts and exceeded their life expectancy (both alive at 1.9 years despite a life expectancy of less than 6 months). Bone marrow blast counts decreased from 22% to 5% in one patient, and from 17% to 16% in the other. CONCLUSION: In conclusion, IGF-MTX at 0.20 μM equivalents per kg was well tolerated, caused no cytopenia, and produced stable disease and extension of life.<p> 28404 Clinical Trials public 2022-02-21T22:48:57.408-06:00