Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-06T14:33:31 RDF description of Association between corticosteroid use and vertebral fractures in older men with chronic obstructive pulmonary disease - http://repository.healthpartners.com/individual/document-rn21096 American Journal of Respiratory and Critical Care Medicine 3 Pt 1 Cross-Sectional Studies 2022-02-21T22:48:57.408-06:00 Drugs and Drug Therapy 157 Association between corticosteroid use and vertebral fractures in older men with chronic obstructive pulmonary disease document-rn21096 Spinal Cord <p>Osteoporosis is a major complication of long-term corticosteroid administration, but the magnitude of the effect in patients with chronic obstructive pulmonary disease (COPD) is not well defined. In a cross-sectional study, we evaluated the association between steroid use and vertebral fractures in 312 men, 50 yr of age or older, with COPD. Subjects were evaluated according to their corticosteroid use: Never Steroid Users (NSU) (n = 117), Inhaled Steroid Users (ISU) (n = 70), and Systemic Steroid Users (SSU) (n = 125). The prevalence of one or more vertebral fractures was 48.7% in the NSU group, 57.1% in the ISU group, and 63.3% in the SSU group. Compared with NSU, SSU were two times as likely to have one or more vertebral fractures: age-adjusted odds ratio (OR) = 1.80; 95% CI, 1.08 to 3.07. This relationship was primarily due to a strong association between continuous systemic steroid use and vertebral fractures: age-adjusted OR = 2.36; 95% CI, 1.26 to 4.38. In addition, fractures in SSU were more likely to be multiple and more severe. A weaker relationship existed between inhaled steroid use and vertebral fractures: age-adjusted OR = 1.35; 95% CI, 0.77 to 2.56 compared with NSU. These data indicate that vertebral fractures are common in older men with COPD; the likelihood of these fractures is greatest in those men using continuous systemic steroids.<p> Adverse Effects Chronic Obstructive Pulmonary Disease Fractures 28116 10.1164/ajrccm.157.3.9703080 16798 Comparative Studies public Osteoporosis