Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-10T20:13:22 RDF description of A comparison of peripheral and central human muscarinic cholinergic receptor affinities for psychotropic drugs - http://repository.healthpartners.com/individual/document-rn20394 2022-02-21T22:48:57.408-06:00 <p>A peripheral model offers a valuable research tool for the investigation of central cholinopathic disorders. The in vitro affinities of several psychotropic drugs for the muscarinic cholinergic binding sites of human caudate and erythrocyte were compared in competition with a tritiated antagonist (quinuclidinyl benzilate). The relative affinities of the drugs for both tissues were strikingly similar. Thus, the erythrocyte muscarinic receptor may represent an accessible in vitro assay for the characterization of central cholinopathic states.<p> A comparison of peripheral and central human muscarinic cholinergic receptor affinities for psychotropic drugs document-rn20394 public 5 Drugs and Drug Therapy 16671 17 Biological Psychiatry Brain 27862