Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-08T13:58:32 RDF description of Glial fibrillary acidic protein and Alzheimer's disease - http://repository.healthpartners.com/individual/document-rn20390 document-rn20390 public 27954 Dementia 2022-02-21T22:48:57.408-06:00 10 Alzheimer's Disease 16717 <p>A major protein associated with Alzheimer's disease (AD) was detected by an electrophoretic study of temporal cortex obtained at autopsy from patients affected with AD, non-AD dementia, and normal controls matched for age and sex. A markedly increased amount of a 50,000 dalton molecular weight protein, which has been identified as glial fibrillary acidic protein (GFAP), was observed in the crude nuclear fraction of temporal cortex from AD patients. These electrophoretic data may reflect the presence of GFAP immunopositive astrocytic processes that have been shown by immunocytologic methods to infiltrate the neurofibrillary tangles that characterize AD.<p> Brain 12 Neurochemical Research 10.1007/bf00988599 Glial fibrillary acidic protein and Alzheimer's disease