Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-08T02:46:19 RDF description of D-aspartate in human brain - http://repository.healthpartners.com/individual/document-rn20389 2022-02-21T22:48:57.408-06:00 public Brain 27856 Journal of Neurochemistry 48 <p>The presence of the biologically uncommon D-aspartic acid (D-aspartate) in human brain white matter has been previously reported. The earlier study has now been expanded to include D/L-aspartate ratios from 67 normal brains. The data show that the D-aspartate content increases rapidly from 1 year to approximately 35 years of age, levels off in middle age, and then appears to decrease somewhat. The D-aspartate content in gray matter remains at a consistently low level (half of that found in white matter) throughout the human life span. Within the limitations of current analytical methods, there was no detectable difference in D/L-aspartate ratios in white and gray matter of brains with Alzheimer's disease and several other pathologies when compared with brains of normal subjects. However, the presence of a significant D-aspartate level in white matter during the adult life span may lead to changes in protein configuration related to dysfunctions associated with the aging brain.<p> Alzheimer's Disease Aging and Geriatrics 16668 10.1111/j.1471-4159.1987.tb04122.x 2 document-rn20389 D-aspartate in human brain