Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-08T04:43:18 RDF description of Seasonal distribution of births in Alzheimer's disease - http://repository.healthpartners.com/individual/document-rn20382 International Psychogeriatrics 16693 2022-02-21T22:48:57.408-06:00 3 10.1017/s1041610291000510 Alzheimer's Disease 27906 Seasonal distribution of births in Alzheimer's disease Cross-Sectional Studies public 1 Epidemiology document-rn20382 <p>We obtained season-of-birth data in 727 autopsy-confirmed cases of Alzheimer's Disease (AD) and compared these data with expected general population birth rates. There were no significant differences between quarterly birth rates in the AD group and expected quarterly birth rates. Edward's test for cyclical trends did not establish a peak period of birth in the AD sample. No significant differences between observed and expected quarterly birth rates were found when data were analyzed with regard to either family history of dementia or to gender. Edward's test for peak quarter was significant for AD females, however, with the peak period occurring early in the first quarter. These negative findings between observed and expected quarterly birth rates, based on the large number of autopsy-confirmed AD cases in this study, suggest that a season-of-birth effect in AD is highly unlikely.<p>