Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-06T21:52:44 RDF description of Risk factors in Alzheimer's disease: a clinicopathologic study - http://repository.healthpartners.com/individual/document-rn20378 16698 Risk Factors <p>We investigated potential risk factors for Alzheimer's disease (AD) in a clinicopathologic study of 407 patients with definite AD, 100 non-Alzheimer dementia patients, and 50 normal subjects. The AD patients had more first-degree relatives with dementia than the non-AD dementia group (odds ratio of 1.85, 95% confidence interval of 1.07-3.20) or the normal elderly (odds ratio of 3.60, 95% confidence interval of 1.50-8.64) but did not have significantly more head injuries, medical and psychiatric illnesses, or relatives with Down's syndrome. The AD patients with a family history of dementia had their dementia at a later age than those without an affected relative. These findings indicate a familial risk for AD that is greater than for other dementing illnesses and has age-related penetrance. This study does not support other putative risk factors for AD such as head trauma and familial Down's syndrome.<p> Dementia Risk factors in Alzheimer's disease: a clinicopathologic study document-rn20378 27916 Genetics 4 2022-02-21T22:48:57.408-06:00 Comparative Studies public 10.1212/wnl.42.4.770 42 Neurology Alzheimer's Disease