Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-11T14:10:40 RDF description of Seizures in Alzheimer's disease: clinicopathologic study - http://repository.healthpartners.com/individual/document-rn20365 document-rn20365 Brain Drugs and Drug Therapy Alzheimer's Disease public 4 10.1177/089198879400700407 <p>New-onset epileptic seizures occur in patients with Alzheimer's disease (AD), but the nature and underlying reasons for these seizures are unclear. We identified new-onset, nonsymptomatic seizures in 77 (17%) of 446 patients with uncomplicated, definite AD on autopsy. Among these seizure patients, 69 had generalized tonic-clonic seizures, and 55 had less than three total seizures. The seizure patients had a younger age of dementia onset than did the remaining AD patients; however, at seizure onset, they averaged 6.8 years into their AD and had advanced dementia. When further compared to 77 AD controls, matched for age of onset and duration, the seizure patients did not differ on medical illnesses, amount of medications, and degree of focal neuropathology. We conclude that a few unprovoked generalized seizures frequently occur late in the course of AD, and that AD patients with a younger age of dementia onset are particularly susceptible to seizures.<p> 27936 Journal of Geriatric Psychiatry and Neurology Seizures in Alzheimer's disease: clinicopathologic study 16708 Comparative Studies 7 2022-02-21T22:48:57.408-06:00 Retrospective Studies