Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-10T20:09:17 RDF description of Quantitative analysis of the olfactory pathway for drug delivery to the brain - http://repository.healthpartners.com/individual/document-rn20364 27980 10.1016/0006-8993(95)00637-6 1-2 Animal Studies document-rn20364 Quantitative analysis of the olfactory pathway for drug delivery to the brain Brain Research Brain <p>Following intranasal administration to rats, wheat germ agglutinin-horseradish peroxidase (WGA-HRP) concentrated in the olfactory nerve and glomerular layers of the olfactory bulb resulting in a mean olfactory bulb concentration of 140 nM. A negligible amount of label was detected in the olfactory bulb following intravenous administration of WGA-HRP or intranasal administration of unconjugated HRP. This is the first quantitative assessment of intraneuronal transport of a protein into the brain using the olfactory route.<p> 16730 public 692 2022-02-21T22:48:57.408-06:00 Intranasal Administration Drugs and Drug Therapy