Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-07T07:19:34 RDF description of Pragmatic trial design of an intervention to reduce cardiovascular risk in people with serious mental illness - http://repository.healthpartners.com/individual/document-rn20337 Health Promotion 2022-02-21T22:48:57.408-06:00 <p>BACKGROUND: Cardiovascular (CV) disease is the leading cause of death for people with serious mental illness (SMI), but clinicians are often slow to address this risk. METHODS/DESIGN: 78 Midwestern primary care clinics were randomized to receive or not receive access to a clinical decision support (CDS) tool. Between March 2016 and September 2018, primary care clinicians (PCPs) received CDS alerts during visits with adult patients with SMI who met minimal inclusion criteria and had at least one CV risk factor not at goal. The PCP CDS included a summary of six modifiable CV risk factors and patient-specific treatment recommendations. Psychiatrists received CDS alerts during their next visit with an eligible patient with SMI that alerted them to an elevated body mass index or recent weight gain and the presence of an obesogenic SMI medication. Study outcomes include total modifiable CV risk, six modifiable CV risk factors, and use of obesogenic SMI medications. DISCUSSION: This cluster-randomized pragmatic trial allowed PCPs and psychiatrists the opportunity to improve CV risk in a timely manner for patients with SMI. Effectiveness will be assessed using an intent-to-treat analysis, and outcomes will be assessed largely through electronic health record data harvested by the CDS tool itself. In total, 10,347 patients with SMI had an index primary care visit in a randomized clinic, and 8937 patients had at least one follow-up visit. Analyses are ongoing, and trial results are expected in mid-2020. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02451670.<p> document-rn20337 Pragmatic Clinical Trials 10.1016/j.cct.2020.105964 Mental Disorders Research Design Clinical Decision Support Systems 16663 Pragmatic trial design of an intervention to reduce cardiovascular risk in people with serious mental illness Cardiovascular Diseases Randomized Controlled Trials 27846 Contemporary Clinical Trials Risk Factors Drugs and Drug Therapy 91 public Primary Health Care