Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-06T23:33:51 RDF description of Post-extrasystolic potentiation as a predictor of recovery of left ventricular dysfunction after radiofrequency catheter ablation - http://repository.healthpartners.com/individual/document-rn2020 document-rn2020 3 12111 11 Post-extrasystolic potentiation as a predictor of recovery of left ventricular dysfunction after radiofrequency catheter ablation Retrospective Studies Cardiovascular Diseases 10.1016/j.jacep.2017.05.017 2022-02-21T22:48:57.408-06:00 Stroke Heart Diseases <p>Objectives: This study hypothesizes that post-extrasystolic potentiation reflects left ventricle contractile reserve and therefore may predict an improvement of premature ventricular contraction (PVC)-induced cardiomyopathy after PVC ablation. Background: Post-extrasystolic potentiation is a physiologic phenomenon of blood pressure accentuation after a PVC beat. Methods: We performed a retrospective study of patients with a PVC burden of �10% PVC/24 h and left ventricular ejection fraction (LVEF) of <50% who underwent successful ablation between January 1, 2009, to June 30, 2015. Subjects were classified as having reversible (a final LVEF �50%) or irreversible (final LVEF <50%) LV dysfunction on a follow-up echocardiogram. A reference (control) group with �10% PVC but normal LV function was also identified. Results: Sixty-one patients (age 68 ± 11 years, 98% male) were studied: 30 with preserved and 31 with reduced LVEF. During median follow-up of 9.4 months, the LVEF of 17 of 31 reduced EF patients improved (reversible) but 14 did not (irreversible). The post-PVC beat systolic blood pressure (SBP) (mm Hg) increase ranged from 12.1 in control subjects (LVEF >50%) to 11.5 in reversible patients to 5 in irreversible patients. In multivariate analysis, the independent predictors of reversible LV function were post-PVC SBP rise (odds ratio [OR]: 4.61; 95% confidence interval [CI]: 1.45 to 15.83 per 5-mm Hg increase; p < 0.001), post-PVC pulse pressure change (OR: 5.2; 95% CI: 2.3 to 18.6 per 5-mm Hg increase; p < 0.001), and PVC QRS duration (OR: 2.78; 95% CI: 1.63 to 10.94 per 10-ms increase; p < 0.001). Conclusions: In patients with LV dysfunction and frequent PVC, post-PVC SBP accentuation may be a marker for subsequent recovery of LVEF after ablation in presumed PVC-induced cardiomyopathy.<p> public Hypertension 18802