Article Document Information Content Entity Continuant Continuant Entity Entity Review Generically Dependent Continuant 2025-05-06T21:57:17 RDF description of Update: adjuncts to mechanical ventilation [review] - http://repository.healthpartners.com/individual/document-rn19832 Drugs and Drug Therapy Current Opinion in Anaesthesiology Respiration, Artificial public Critical Care Anesthesia 13477 10.1097/ACO.0b013e32834f8c65 21534 Update: adjuncts to mechanical ventilation [review] Respiratory Tract Diseases document-rn19832 2022-02-21T22:48:57.408-06:00 review 25 <p>PURPOSE OF REVIEW: To describe the most recent advances and clinical applications of adjunctive techniques in mechanical ventilation, focusing on their overall impact on mortality and their potential indications in critically ill patients. RECENT FINDINGS: The modern variants of extracorporeal membrane oxygenation are not only rescue alternatives but also therapeutic options for patients with severe but potentially reversible acute respiratory distress syndrome. Prone positioning returns as a desirable therapeutic option for patients with severe acute respiratory distress syndrome. Recent reports suggest that permissive hypercapnia, therapeutic paralysis, sedation, and controlled hypothermia could potentially improve important clinical outcomes. Although more clinical trials are clearly needed to support the use of inhaled prostacyclins in severe respiratory failure, encouraging results have been described in recent publications. SUMMARY: Giving the complexity and dynamism of acute lung injury, timing, severity, and pathophysiologic pertinence are mandatory components of decision-making when considering the application of adjunctive measures to support mechanical ventilation.<p> Injuries Lung 2