Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-06T12:52:32 RDF description of Lysosomal enzyme can bypass the blood-brain barrier and reach the CNS following intranasal administration - http://repository.healthpartners.com/individual/document-rn19751 Molecular Genetics and Metabolism public 106 Blood 2022-02-21T22:48:57.408-06:00 13108 1 Brain 10.1016/j.ymgme.2012.02.006 <p>Here we provide the first evidence that therapeutic levels of a lysosomal enzyme can bypass the blood-brain barrier following intranasal administration. alpha-L-iduronidase (IDUA) activity was detected throughout the brains of IDUA-deficient mice following a single intranasal treatment with concentrated Aldurazyme(R) (laronidase) and was also detected after intranasal treatment with an adeno-associated virus (AAV) vector expressing human IDUA. These results suggest that intranasal routes of delivery may be efficacious in the treatment of lysosomal storage disorders.<p> Drugs and Drug Therapy Genetics document-rn19751 Lysosomal enzyme can bypass the blood-brain barrier and reach the CNS following intranasal administration 20796 Intranasal Administration Animal Studies