Article Document Academic Article Information Content Entity Journal Article Continuant Continuant Entity Entity Generically Dependent Continuant 2025-06-24T07:47:49 RDF description of Smaller intracranial volume in prodromal Huntington's disease: evidence for abnormal neurodevelopment - http://repository.healthpartners.com/individual/document-rn19587 Pt 1 Smaller intracranial volume in prodromal Huntington's disease: evidence for abnormal neurodevelopment Brain Genetics <p>Huntington's disease is an autosomal dominant brain disease. Although conceptualized as a neurodegenerative disease of the striatum, a growing number of studies challenge this classic concept of Huntington's disease aetiology. Intracranial volume is the tissue and fluid within the calvarium and is a representation of the maximal brain growth obtained during development. The current study reports intracranial volume obtained from an magnetic resonance imaging brain scan in a sample of subjects (n = 707) who have undergone presymptomatic gene testing. Participants who are gene-expanded but not yet manifesting the disease (prodromal Huntington's disease) are compared with subjects who are non-gene expanded. The prodromal males had significantly smaller intracranial volume measures with a mean volume that was 4% lower compared with controls. Although the prodromal females had smaller intracranial volume measures compared with their controls, this was not significant. The current findings suggest that mutant huntingtin can cause abnormal development, which may contribute to the pathogenesis of Huntington's disease.<p> Brain Nervous System Diseases 21068 public 13244 Radiography 134 2022-02-21T22:48:57.408-06:00 document-rn19587 10.1093/brain/awq280