Article Document Information Content Entity Continuant Continuant Entity Entity Review Generically Dependent Continuant 2025-05-07T17:35:45 RDF description of Burn resuscitation [review] - http://repository.healthpartners.com/individual/document-rn19423 10.1186/1757-7241-19-69 Critical Care public 11957 document-rn19423 Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2022-02-21T22:48:57.408-06:00 review 18494 Resuscitation Burn resuscitation [review] Drugs and Drug Therapy Burns <p>Fluid resuscitation following burn injury must support organ perfusion with the least amount of fluid necessary and the least physiological cost. Under resuscitation may lead to organ failure and death. With adoption of weight and injury size-based formulas for resuscitation, multiple organ dysfunction and inadequate resuscitation have become uncommon. Instead, administration of fluid volumes well in excess of historic guidelines has been reported. A number of strategies including greater use of colloids and vasoactive drugs are now under investigation to optimize preservation of end organ function while avoiding complications which can include respiratory failure and compartment syndromes. Adjuncts to resuscitation, such as antioxidants, are also being investigated along with parameters beyond urine output and vital signs to identify endpoints of therapy. Here we briefly review the state-of-the-art and provide a sample of protocols now under investigation in North American burn centers.<p> 19