Article Document Academic Article Information Content Entity Journal Article Continuant Continuant Entity Entity Generically Dependent Continuant 2025-05-06T21:53:40 RDF description of Factors associated with prevalent abnormal anal cytology in a large cohort of HIV-infected adults in the United States - http://repository.healthpartners.com/individual/document-rn19292 Drugs and Drug Therapy public Cohort Studies Factors associated with prevalent abnormal anal cytology in a large cohort of HIV-infected adults in the United States Questionnaires 2022-02-21T22:48:57.408-06:00 10 202 15105 <p>BACKGROUND: The prevalence of and risk factors for abnormal anal cytology among men and women with human immunodeficiency virus (HIV) infection have not been extensively investigated. METHODS: The Study to Understand the Natural History of HIV and AIDS in the Era of Effective Therapy (SUN study) is a prospective cohort study of HIV-infected patients in 4 US cities. Baseline questionnaires were administered and anal samples for cytology and human papillomavirus (HPV) detection and genotyping were collected. RESULTS: Among 471 men and 150 women (median age, 41 years), 78% of participants were receiving combination antiretroviral therapy, 41% had a CD4(+) cell count of >/=500 cells/muL, and 71% had an HIV RNA viral load of <400 copies/mL. The anal cytology results were as follows: 336 participants (54%) had negative results, 96 participants (15%) had atypical squamous cells, 149 participants (24%) had low-grade squamous intraepithelial lesions, and 40 participants (6%) had high-grade squamous intraepithelial lesions. In a multivariate analysis, abnormal anal cytology was associated with number of high-risk and low-risk HPV types (adjusted odds ratio [AOR] for both, 1.28; P < .001), nadir CD4(+) cell count of <50 cells/muL (AOR, 2.38; P = .001), baseline CD4(+) cell count of <500 cells/muL (AOR, 1.75; P = .004), and ever having receptive anal intercourse (AOR, 2.51; P < .001). CONCLUSION: HIV-infected persons with multiple anal HPV types or a nadir CD4(+) cell count of <50 cells/muL have an increased risk for abnormal anal cytology.<p> HIV-AIDS Journal of Infectious Diseases 10.1086/656775 24790 document-rn19292 Cross-Sectional Studies