Article Document Information Content Entity Continuant Continuant Entity Entity Review Generically Dependent Continuant 2025-05-07T10:37:40 RDF description of Cold injury [review] - http://repository.healthpartners.com/individual/document-rn19058 Critical Care Hand 25322 4 public Injuries <p>The pathophysiology of true frostbite reveals that the direct injury produced during the initial freeze process has a minor contribution to the global tissue damage. However, rapid rewarming to reverse the tissue crystallization has essentially been the lone frostbite intervention for almost half a century. The major pathologic process is the progressive microvascular thrombosis following reperfusion of the ischemic limb, with the cold-damaged endothelial cells playing a central role in the outcome of these frozen tissues. Newer interventions offer the opportunity to combat this process, and this article offers a scientific approach to frostbite injuries of the upper extremities.<p> review 15371 25 Risk Factors document-rn19058 2022-02-21T22:48:57.408-06:00 Hand Clinics 10.1016/j.hcl.2009.06.004 Cold injury [review]