Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-06T21:54:24 RDF description of Intranasal administration delivers peptoids to the rat central nervous system - http://repository.healthpartners.com/individual/document-rn18932 Animal Studies 2022-02-21T22:48:57.408-06:00 public Neuroscience Letters 14946 1 10.1016/j.neulet.2008.04.097 24472 439 <p>Intranasal administration of therapeutic agents offers a noninvasive method of drug delivery that bypasses the blood-brain barrier and directly targets the central nervous system (CNS) and lymph nodes. We examined whether intranasal peptoid CHIR5585, an antagonist of the urokinase plasminogen activator receptor (uPAR), is delivered to the CNS. Peptoids are a novel class of peptide isomers that are oligomeric N-substituted glycine peptides. Anesthetized male rats were administered peptoid CHIR5585 intranasally, and tissue distribution was evaluated quantitatively by gamma counting and qualitatively by autoradiography. Intranasal administration resulted in significant delivery throughout the CNS (olfactory bulbs, 3.9microM; cortex, 0.3microM; trigeminal nerve, 1.7microM) and deep cervical lymph nodes (4.5microM). Autoradiography demonstrated a similar delivery pattern to the CNS.<p> document-rn18932 Intranasal administration delivers peptoids to the rat central nervous system Intranasal Administration Drugs and Drug Therapy