Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-10T20:02:08 RDF description of Biological clocks and shift work: circadian dysregulation and potential long-term effects - http://repository.healthpartners.com/individual/document-rn18715 10.1007/s10552-005-9015-4 *Work Schedule Tolerance Adaptation, Physiological document-rn18715 Chronobiology Disorders/*complications/physiopathology Animals Cancer Causes and Control Biological clocks and shift work: circadian dysregulation and potential long-term effects 12858 Neoplasms/etiology Occupational Diseases/*etiology 17 4 Biological Clocks Chronobiology Phenomena public Risk Factors Suprachiasmatic Nucleus/physiopathology <p>Long-term epidemiologic studies on large numbers of night and rotating shift workers have suggested an increase in the incidence of breast and colon cancer in these populations. These studies suffer from poor definition and quantification of the work schedules of the exposed subjects. Against this background, the pathophysiology of phase shift and phase adaptation is reviewed. A phase shift as experienced in night and rotating shift work involves desynchronization at the molecular level in the circadian oscillators in the central nervous tissue and in most peripheral tissues of the body. There is a change in the coordination between oscillators with transient loss of control by the master-oscillator (the Suprachiasmatic Nucleus, SCN) in the hypothalamus. The implications of the pathophysiology of phase shift are discussed for long-term health effects and for the design of ergonomic work schedules minimizing the adverse health effects upon the worker.<p> 20296 2022-02-21T22:48:57.408-06:00 Cardiovascular Abnormalities/etiology