Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-09T09:57:43 RDF description of Persistent neuropathy and hyperkeratosis from distant arsenic exposure - http://repository.healthpartners.com/individual/document-rn18687 Neural Conduction/drug effects <p>The purpose of this case series is to assess long-term sequelae of arsenic exposure in a cohort acutely exposed to arsenic in drinking water from a well dug into a landfill containing arsenical pesticides. Ten of the 13 individuals (or next of kin) in the initial study agreed to participate in the follow-up study. Next of kin provided questionnaire data and released medical information on the three individuals who had died. The remaining seven cohort members were assessed by an interview, questionnaire, detailed physical examination and sensory nerve testing. Available medical records were obtained and reviewed. Sensory testing was performed using an automated electrodiagnostic sensory Nerve Conduction Threshold (sNCT) evaluation. Sensory complaints and electrodiagnostic findings consistent with polyneuropathy were found in a minority (3/7) of subjects 28 years after an acute toxic arsenic exposure. Two of the seven patients examined (1 of 3 with neuropathic findings) also had hyperkeratotic lesions consistent with arsenic toxicity and one of the patients had hyperpigmentation on their lower extremities possibly consistent with arsenic toxicity.<p> 19748 Cohort Studies public Water Supply Arsenic/*adverse effects 10 Skin Diseases/chemically induced/*epidemiology/pathology Arsenic Poisoning/mortality/*physiopathology Fatal Outcome Peripheral Nervous System Diseases/chemically induced/*epidemiology/pathology 10.1300/J096v10n04_07 Journal of agromedicine 2022-02-21T22:48:57.408-06:00 4 document-rn18687 Persistent neuropathy and hyperkeratosis from distant arsenic exposure 12584