Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-06T12:52:26 RDF description of Intranasal administration of interferon beta bypasses the blood-brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis - http://repository.healthpartners.com/individual/document-rn18585 Rats Immunosuppressive Agents/*administration & dosage/metabolism Lymph Nodes Multiple Sclerosis/*drug therapy 1-2 Brain Chemistry Autoradiography Comparative Studies Blotting, Western Tissue Distribution Journal of Neuroimmunology Cervical Vertebrae Brain 12445 public 19470 Drugs and Drug Therapy Interferon-beta/*administration & dosage/metabolism 2022-02-21T22:48:57.408-06:00 Intranasal administration of interferon beta bypasses the blood-brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis Injections, Intravenous Intranasal Administration Animal Studies Central Nervous System/*chemistry/metabolism Blood-Brain Barrier/*physiology 151 10.1016/j.jneuroim.2004.02.011 <p>Intranasal (i.n.) administration of IFN beta-1b was examined as a route for targeted delivery to the rat central nervous system (CNS). Intranasal administration resulted in significant delivery throughout the CNS and cervical lymph nodes with low delivery to peripheral organs. At similar blood levels, intravenous (i.v.) administration of IFN beta-1b yielded 88-98% lower CNS levels and 100-1650% greater peripheral organ levels compared to intranasal. Autoradiography confirmed much greater delivery to the CNS with intranasal administration. Intranasally administered IFN beta-1b reached the brain intact and produced tyrosine phosphorylation of IFN receptor in the CNS. Intranasal administration offers a non-invasive method of drug delivery for multiple sclerosis (MS) that bypasses the blood-brain barrier (BBB) and directly targets the CNS and lymph nodes.<p> document-rn18585