Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-06T14:32:24 RDF description of Twice-daily triple nucleoside intensification treatment with lamivudine-zidovudine plus abacavir sustains suppression of human immunodeficiency virus type 1: results of the TARGET Study - http://repository.healthpartners.com/individual/document-rn18423 document-rn18423 10.1086/318527 Aged 23834 Journal of Infectious Diseases Lamivudine/administration & dosage/*therapeutic use public Viral Load Dideoxynucleosides/administration & dosage/*therapeutic use <p>This open-label, multicenter, single-arm clinical trial assessed the 48-week efficacy of a twice-daily triple nucleoside reverse-transcriptase inhibitor regimen containing a lamivudine (150 mg)-zidovudine (300 mg) combination tablet (COM) and abacavir (ABC; 300 mg) in 87 antiretroviral therapy-experienced, protease inhibitor-naive patients infected with human immunodeficiency virus type 1 (HIV-1). At baseline, the median plasma HIV-1 RNA level was 3.10 log(10) copies/mL, and the median CD4 cell count was 506 cells/mm(3). An intent-to-treat&rcolon;observed analysis showed that, at weeks 24 and 48 of treatment, HIV-1 RNA level was <400 copies/mL in 48 (76%) of 63 and 45 (82%) of 55 patients, respectively, and <50 copies/mL in 37 (59%) of 63 and 31 (56%) of 55 patients, respectively. Previous zidovudine or lamivudine use and presence at baseline of the M184V reverse-transcriptase mutation did not impact virologic response. Median CD4 cell counts were maintained above baseline throughout the study. COM plus ABC was generally well tolerated.<p> 4 RNA, Viral/blood 2022-02-21T22:48:57.408-06:00 14627 HIV Infections/*drug therapy/virology 183 Twice-daily triple nucleoside intensification treatment with lamivudine-zidovudine plus abacavir sustains suppression of human immunodeficiency virus type 1: results of the TARGET Study CD4 Lymphocyte Count Reverse Transcriptase Inhibitors/*therapeutic use Zidovudine/administration & dosage/*therapeutic use Anti-HIV Agents/administration & dosage/*therapeutic use HIV-1/genetics/physiology Drug Therapy, Combination Treatment Outcome