Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-06T20:12:15 RDF description of Recruitment maneuvers in three experimental models of acute lung injury. Effect on lung volume and gas exchange - http://repository.healthpartners.com/individual/document-rn18385 Pneumonia, Bacterial document-rn18385 10.1164/ajrccm.161.5.9809014 public Respiratory Distress Syndrome, /etiology/*physiopathology/therapy <p>Recruitment maneuvers (RM), consisting of sustained inflations at high airway pressures, have been advocated as an adjunct to mechanical ventilation in acute respiratory distress syndrome (ARDS). We studied the effect of baseline ventilatory strategy and RM on end-expiratory lung volume (EELV) and oxygenation in 18 dogs, using three models of acute lung injury (ALI; n = 6 in each group): saline lavage (LAV), oleic acid injury (OAI), and intratracheal instillation of Escherichia coli (pneumonia; PNM). All three models exhibited similar degrees of lung injury. The PNM model was less responsive to positive end-expiratory pressure (PEEP) than was the LAV or OAI model. Only the LAV model showed an oxygenation response to increasing tidal volume (VT). After RM, there were transient increases in Pa(O(2)) and EELV when ventilating with PEEP = 10 cm H(2)O. At PEEP = 20 cm H(2)O the lungs were probably fully recruited, since the plateau airway pressures were relatively high ( approximately 45 cm H(2)O) and the oxygenation was similar to preinjury values, thus making the system unresponsive to RM. Sustained improvement in oxygenation after RM was seen in the LAV model when ventilating with PEEP = 10 cm H(2)O and VT = 15 ml/kg. Changes in EELV correlated with changes in Pa(O(2)) only in the OAI model with PEEP = 10 cm H(2)O. We conclude that responses to PEEP, VT, and RM differ among these models of ALI. RM may have a role in some patients with ARDS who are ventilated with low PEEP and low VT.<p> Respiration, Artificial American Journal of Respiratory and Critical Care Medicine *Disease Models, Animal 5 17112 Functional Residual Capacity 2022-02-21T22:48:57.408-06:00 11266 Positive-Pressure Respiration/*methods Tidal Volume Recruitment maneuvers in three experimental models of acute lung injury. Effect on lung volume and gas exchange *Lung Volume Measurements Oxygen/blood Oleic Acid Dogs *Pulmonary Gas Exchange Hemodynamics Animals Sodium Chloride 161