Article Document Information Content Entity Continuant Continuant Entity Entity Review Generically Dependent Continuant 2025-05-10T19:59:35 RDF description of Skin sensitization induction risk assessment of common ingredients in commercially available cleansing conditioners [review] - http://repository.healthpartners.com/individual/document-rn13829 30 <p>BACKGROUND: An essential step in ensuring the toxicological safety of cosmetic or personal care products is the evaluation of the skin sensitizing potential of product ingredients. OBJECTIVE: We used a standardized protocol from cosmetic trade industry and consumer safety groups to evaluate the sensitization potential of ingredients in 3 commercially available cleansing conditioners. METHODS: A total of 33 ingredients were evaluated. Each ingredient underwent (1) dermatological evaluation, (2) in silico analysis for irritation and sensitization potential, and (3) a literature evaluation to determine risk of sensitization. Consumer exposure level was compared with the weight-of-evidence no-expected sensitization induction level for the constituent. If a no-expected sensitization induction level for a specific ingredient was not available, the dermal sensitization threshold approach was used. A margin of safety was calculated for each constituent. RESULTS: The margins of safety for all evaluated ingredients in the cleansing conditioners were greater than 1. CONCLUSIONS: This analysis indicates that exposure to the individual ingredients present in these cleansing conditioners would not be expected to induce dermal sensitization in a consumer under the examined exposure scenario.<p> 12039 Risk Assessment Rhinitis, Allergic Skin sensitization induction risk assessment of common ingredients in commercially available cleansing conditioners [review] review 2 document-rn13829 18658 Adverse Effects 2022-02-21T22:48:57.408-06:00 Skin Diseases Dermatitis Simulation 10.1097/der.0000000000000445 public