Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-06-24T09:27:24 RDF description of Case report of extended survival and quality of life in a melanoma patient with multiple brain metastases and review of literature - http://repository.healthpartners.com/individual/document-rn13827 16918 Skin Cancer 9 Cureus public 10.7759/cureus.1947 Brain Cancer 11169 Quality of Life 2022-02-21T22:48:57.408-06:00 document-rn13827 <p>Long-term survival for melanoma patients with multiple brain metastases is rare. A review of the literature reveals only three reported melanoma patients with multiple brain metastases who survived more than 10 years. We present a patient who is recurrence-free 11 years after the diagnosis of three brain metastases. Her treatment consisted of cytokine (interferon and interleukin-2) and chemotherapy nine months prior to developing brain and soft tissue metastases, which were treated with stereotactic radiosurgery and stereotactic ablative radiotherapy, respectively, followed by six months of chemotherapy. Notably, she has not received any treatment for over 10 years, never underwent craniotomy or whole brain radiation therapy, currently has a perfect score on the functional assessment of cancer therapy for brain (FACT-Br) quality of life (QoL) scale, and runs marathons. This treatment course is consistent with emerging literature on the abscopal effect (radiation-induced immune response). Clinical trials are needed to better understand and harness the abscopal effect in order to optimally integrate targeted drug and radiation therapies.<p> Case report of extended survival and quality of life in a melanoma patient with multiple brain metastases and review of literature 12 Drugs and Drug Therapy Chemotherapy