Article Document Academic Article Information Content Entity Continuant Continuant Journal Article Entity Entity Generically Dependent Continuant 2025-05-07T20:41:51 RDF description of Predictors of long-term survival among high-grade serous ovarian cancer patients - http://repository.healthpartners.com/individual/document-rn12107 Cancer Epidemiology, Biomarkers and Prevention Survivors document-rn12107 Chemotherapy Retrospective Studies 5 15364 Mortality Ovarian Cancer 2022-02-21T22:48:57.408-06:00 28 10.1158/1055-9965.epi-18-1324 <p>BACKGROUND: Relatively little is known about factors associated with long-term survival (LTS) following a diagnosis of ovarian cancer. METHODS: We conducted a retrospective study of high-grade serous ovarian cancer (HGSOC) to explore predictors of LTS (defined as >/=7 years of survival) using electronic medical record data from a network of integrated health care systems. Multivariable logistic regression with forward selection was used to compare characteristics of women who survived >/=7 years after diagnosis (n = 148) to those who died within 7 years of diagnosis (n = 494). RESULTS: Our final model included study site, age, stage at diagnosis, CA-125, comorbidity score, receipt of chemotherapy, BMI, and four separate comorbid conditions: weight loss, depression, hypothyroidism, and liver disease. Of these, only younger age, lower stage, and depression were statistically significantly associated with LTS. CONCLUSIONS: We did not identify any new characteristics associated with HGSOC survival. IMPACT: Prognosis of ovarian cancer generally remains poor. Large, pooled studies of ovarian cancer are needed to identify characteristics that may improve survival.<p> public Forecasting 25308 Predictors of long-term survival among high-grade serous ovarian cancer patients Follow-Up Studies